Sr Principal Engineer - Data
Eli Lilly and Company13 days ago
Indianapolis, IN, USAStaff+
Base Salary
$129k - $211k/yr
Responsibilities
- Own technical architecture and end-to-end production delivery for agentic AI and data modernization solutions across supply chain and manufacturing.
- Set reusable standards for cloud data modeling, pipeline design, agent orchestration, evaluation, and production support.
- Mentor junior and mid-level engineers, lead code and design reviews, and provide technical direction.
- Partner with business and IT leaders on roadmaps, delivery sequencing, build-versus-buy decisions, and vendor accountability.
- Model and correlate supply chain and manufacturing data across ERP, planning, MES, historian, quality, and logistics systems.
- Design, build, deploy, evaluate, and monitor AI agents, multi-agent workflows, predictive models, and machine learning systems.
- Build and maintain scalable ETL/ELT pipelines and modern lakehouse/cloud data architectures.
- Monitor data quality and agent behavior, document architectures and deployments, and support GxP/CSV, privacy, security, and responsible AI requirements.
Requirements
- Bachelor’s degree in Computer Science, Engineering, Data Science, Statistics, Supply Chain, or a related field and 8+ years of experience in data engineering, analytics, or AI/ML, including hands-on production generative AI or agentic application delivery.
- Hands-on experience with supply chain and manufacturing data, SAP S/4HANA or ECC, SAP BW/4HANA, SHARP, MES, and related analytics.
- Advanced experience with statistical methods, machine learning, LLM and agentic application development, prompt engineering, tool or function calling, RAG, vector search, embeddings, and multi-step workflows.
- Deep knowledge of agent frameworks such as LangChain or LangGraph and production LLM APIs such as OpenAI, Azure OpenAI, Anthropic, or Bedrock.
- Advanced Python skills; SQL, Java, Scala, and R experience are advantageous.
- Experience developing and operating production-grade analytics systems end to end.
- Preferred qualifications include a master’s degree with 5+ years of relevant experience, regulated manufacturing or pharmaceutical supply chain experience, production AI solution delivery, SAP IBP, Kinaxis, o9, IoT or streaming data, OSI PI, TrakSYS, PMX, LIMS, GxP/CSV validation, Power BI, responsible AI, globally distributed team or vendor leadership, and Databricks, AWS, or Azure certifications.
Benefits
- Full-time position located in Indianapolis, Indiana, with onsite work required five days per week.
- Eligible employees may receive a company bonus based partly on company and individual performance.
- Benefits may include a 401(k), pension, vacation, medical, dental, vision, prescription drug, flexible spending, life insurance, leave, employee assistance, fitness, and employee club benefits.
Categories
About Eli Lilly and Company
Eli Lilly and Company researches, develops, manufactures, and markets prescription medicines and biologics for patients, sold through healthcare providers, pharmacies, and payers. Core therapeutic areas include diabetes, oncology, immunology, neuroscience, and obesity. Founded in 1876 and headquartered in Indianapolis, it is a public company (NYSE: LLY) with global operations and is building a new advanced manufacturing site for gene therapy and other modalities in Lebanon, Indiana.