Principal Software Algorithm Engineer - Digital Cytology AI
Hologic, Inc.3 days ago
Marlborough, MA, USAStaff+
Base Salary
$157k - $220k/yr
Responsibilities
- Design, train, tune, and validate multi-class CNNs for cell classification and specimen-level diagnostic categorization.
- Develop multi-task models and nucleus/cytoplasm segmentation networks for cytomorphologic features, nuclear area, and nuclear-to-cytoplasmic ratio measurement.
- Own data preparation and pipeline practices, including patient-grouped splits, color profiles, class balancing, imaging metadata, and leakage prevention.
- Run experiments, benchmark lightweight and reference models, define evaluation metrics, and produce technical reports.
- Collaborate with pathologists on labeling protocols, inter-observer agreement, and adjudication processes.
- Prepare design documentation, verification and validation protocols, and technical content for regulatory submissions.
- Mentor engineers and establish coding, reproducibility, and MLOps standards.
- Evaluate model performance and interpretability using Grad-CAM and pathologist-aligned feature outputs.
- Support regulatory strategy for AI-enabled medical devices under design controls and PCCP guidance.
Requirements
- MS or PhD in computer science, biomedical engineering, electrical engineering, or a related field, or a BS with equivalent experience.
- 10+ years of software development experience, including 5+ years building and deploying deep learning models for computer vision.
- Demonstrated leadership in setting strategic direction, influencing senior stakeholders, leading cross-functional initiatives, and driving execution.
- Expert Python and PyTorch or TensorFlow skills, including CNN fine-tuning, transfer learning, and segmentation.
- Experience with imbalanced, multi-class, and multi-task problems and metrics including per-class sensitivity, F1, kappa, and AUROC.
- Experience with medical or microscopy imaging, including color handling, stain variation, and high-resolution tiling.
- Strong practices in data splitting, leakage prevention, experiment tracking, and reproducible training.
- Clear written communication for technical reports and design documentation.
- Preferred experience with digital pathology or cytology AI, FDA 510(k), De Novo, PMA, EU IVDR, IEC 62304, ISO 13485, ISO 14971, 21 CFR Part 820, or FDA PCCP guidance.
- Preferred familiarity with ICC color management, stain deconvolution, scanner color calibration, cell instance segmentation, annotation tools, and edge or embedded inference optimization.
- Preferred experience leading or technically guiding a small team.
Benefits
- Comprehensive training upon joining and continued development and training throughout the career.
- Annualized base salary of $157,000 - $220,000 and bonus eligibility.
Categories
About Hologic, Inc.
Hologic builds breast and skeletal imaging systems, molecular diagnostic platforms and assays, and GYN surgical devices used by hospitals, imaging centers, and clinical labs. Its business model combines capital equipment sales with recurring revenue from consumables, assays, and service contracts. Founded in 1985 and headquartered in Marlborough, Massachusetts, Hologic is listed on Nasdaq (HOLX) and is associated with 3D mammography and the Panther molecular testing platform.