Lila Sciences

Sr Principal/Principal Software Engineer, App

Lila Sciences
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3 months ago
Cambridge, MA, USA or San Francisco, CA, USAStaff+
H1B Sponsor

Base Salary

$204k - $348k/yr

Responsibilities

  • Design and build high-performance, secure, and well-documented user interfaces and APIs for AI-driven applications.
  • Develop database schemas and manage SQL, NoSQL, vector, and other data systems for performance and scalability.
  • Implement front-end and backend services with a focus on performance, maintainability, and reliability.
  • Diagnose bottlenecks and optimize high-availability, low-latency systems for large-scale workloads.
  • Use AWS services and Kubernetes to build and deploy production-grade systems at scale.
  • Integrate data pipelines, APIs, and cloud infrastructure into scientific workflows in collaboration with ML researchers, engineers, and scientists.
  • Build agents, interfaces, and platform integrations that enable researchers to collaborate with AI.

Requirements

  • Bachelor’s or Master’s degree in Computer Science, Engineering, or a related field.
  • 8–15 years of engineering experience building and deploying large-scale production systems.
  • Strong expertise in either front-end or backend engineering, with full-stack web application development experience.
  • Experience with React, TypeScript, monorepos such as Nx, Tailwind, FastAPI, SQL or NoSQL systems, Python, and Pydantic.
  • Hands-on experience using AI coding assistants is required.
  • Proven cross-functional collaboration with scientists, data engineers, and product teams.
  • Ability to own complex backend challenges and balance scalability, performance, and maintainability.
  • Preferred experience includes AI agents, graph-based workflows, MCP, RAG pipelines, or LLM orchestration frameworks.
  • Preferred experience includes AWS, Kubernetes, containerization, Terraform, CloudFormation, and GitHub Actions.
  • Preferred experience includes SQLModel, FastAPI, Django, Airflow, Prefect, Temporal, Dagster, pandas, NumPy, SciPy, JAX, and PyTorch.
  • Laboratory software, life sciences, material sciences, laboratory devices, robotics, or hardware-driver experience is a bonus.

Benefits

  • Medical, dental, and vision coverage for full-time U.S. employees
  • Employer-paid life and disability insurance
  • Flexible time off and company-wide holidays
  • Paid parental leave
  • Educational assistance program
  • Commuter benefits, including bike-share memberships for office-based employees
  • Company-subsidized lunch program
  • Regionally tailored benefits for international full-time employees

Tech Stack

Apache AirflowAWSDjangoFastAPIGitHub ActionsKubernetesNumPyPandasPythonPyTorchReactSciPySQLTailwind CSSTerraformTypeScript
Lila Sciences

About Lila Sciences

201-500 employees

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science. We are building the foundation to apply AI to every aspect of the scientific method, enabling scientists to bring forth solutions in human health and sustainability at a pace and scale never experienced before.