Senior Engineer I/II, Drug Discovery Platform

6 days ago

Cambridge, MA, USASenior

H1B Sponsor

Base Salary

$148k - $240k/yr

Responsibilities

Design and operate the molecule queue that brokers compounds between AI Scientists and the Make-Test platform, including state management, batching, prioritization, and read/write contracts.
Build the canonical compound and structure registry with SMILES/InChI normalization, stereochemistry handling, salt and parent resolution, duplicate detection, and stable internal identifiers.
Create pipelines for ChemSpeed synthesis, LCMS, NMR, and bioassay-reader data, capturing identity, purity, dose-response, IC50/EC50, ADMET, and selectivity results.
Maintain synthesis constraints and inventory state covering building blocks, advanced precursors, ChemSpeed capacity, stock alerts, reaction types, step budgets, and solvent compatibility.
Own data quality, lineage, schema evolution, observability, and service-level targets for the computational-to-experimental feedback loop.

Bachelor’s or master’s degree in computer science, chemistry, computational biology, or a related field.
5+ years of experience building production data platforms, ideally with scientific or laboratory-generated data.
Experience designing and shipping ingestion frameworks, registries, storage abstractions, and orchestration systems from the ground up.
Fluency in backend production APIs and services, Python, and SQL, with production-quality coding skills.
Production experience with relational and/or NoSQL databases, evolving scientific schemas, query optimization, and structured, semi-structured, and unstructured data.
Ability to model chemical and biological data, including structures, reactions, assays, dose-response data, batches, replicates, censored values, and failed runs.
Experience with AWS and containerized deployment using Kubernetes.
Proficiency with AI-assisted development tools such as Cursor, Claude Code, or similar.
Preferred experience with RDKit, OpenEye, CDD Vault, Dotmatics, Benchling Registry, ELN/LIMS, mzML, AnIML, Flyte, Airflow, Dagster, Temporal, Iceberg, Delta Lake, Hudi, DuckDB, Polars, Spark, ChemSpeed, Chemspeed SWING, Opentrons, or HTS readers.
Preferred domain experience includes pharma, biotech, academic drug discovery, SAR, ADMET, IC50/EC50, DEL screening, and infrastructure for agentic or LLM-driven workflows.

Full-time U.S. employees receive medical, dental, and vision coverage.
Employer-paid life and disability insurance are provided.
Employees receive flexible time off, generous company-wide holidays, and paid parental leave.
Educational assistance, commuter benefits including bike-share memberships for office-based employees, and a company-subsidized lunch program are available.
International full-time employees receive regionally tailored benefits.