Sr. Principal Software Engineer- Full Stack
Eli Lilly and Company1 day ago
Indianapolis, IN, USAStaff+
Base Salary
$129k - $211k/yr
Responsibilities
- Build and ship full-stack applications across frontend, backend, API, and data layers from problem scoping through production iteration.
- Develop software using Next.js, React, TypeScript, Node.js, Python, GraphQL, and Neo4j.
- Use AI-assisted development tools to accelerate design and implementation while validating generated output and maintaining engineering quality.
- Contribute to architecture decisions, design documents, technical specifications, testing, observability, and version-control workflows.
- Flex across frontend, backend, data engineering, and DevOps work while collaborating with distributed teammates, product managers, and stakeholders.
- Containerize and deploy applications with Docker and Kubernetes/EKS, troubleshoot pods and clusters, and investigate networking, logs, IAM policies, and cloud resources.
- Manage reliable deployment pipelines with Argo CD and Argo Workflows.
- Mentor junior engineers, lead design reviews, and raise the technical capabilities of the team.
Requirements
- Bachelor’s degree in Computer Science, Software Engineering, or a related technical field.
- At least 5 years of professional software engineering experience building and shipping production applications across frontend and backend technologies.
- Strong computer science fundamentals, including data structures, algorithms, systems design, networking, and understanding of software beneath framework abstractions.
- Experience with React or Next.js and at least one backend language such as Python, Node.js, Go, or Java.
- Hands-on experience with Docker, Kubernetes, CI/CD pipelines, AWS or equivalent cloud-native deployment, and production troubleshooting.
- Experience with relational, document, or graph database paradigms and scalable data modeling.
- At least 1 year of regular hands-on use of AI-assisted development tools such as Claude Code, GitHub Copilot, or Cursor.
- Preferred qualifications include a master’s degree; 5–8+ years of experience owning complete systems; Neo4j and GraphQL experience; developer platform or internal tooling experience; agentic AI, LLM integration, MCP, or multi-agent orchestration familiarity; observability tooling experience; and biopharma or healthcare background.
- Ability to mentor engineers, lead design reviews, communicate technical tradeoffs clearly, and make decisions in ambiguous environments.
Benefits
- Full-time employees may be eligible for a company bonus, 401(k), pension, vacation, medical, dental, vision, prescription drug, flexible spending, life insurance, leave, employee assistance, fitness, and employee club benefits.
Tech Stack
Argo CDAWSDatadogDockerGoGrafanaGraphQLJavaJavaScriptKubernetesNeo4jNext.jsNode.jsPrometheusPythonReactSplunkTypeScript
Categories
About Eli Lilly and Company
Eli Lilly and Company researches, develops, manufactures, and markets prescription medicines and biologics for patients, sold through healthcare providers, pharmacies, and payers. Core therapeutic areas include diabetes, oncology, immunology, neuroscience, and obesity. Founded in 1876 and headquartered in Indianapolis, it is a public company (NYSE: LLY) with global operations and is building a new advanced manufacturing site for gene therapy and other modalities in Lebanon, Indiana.