Natera

Principal Software Engineer

Natera
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13 hours ago
South San Francisco, CA, USAStaff+
H1B sponsor

Base Salary

$220k - $275k/yr

Responsibilities

  • Own the architecture, implementation, and delivery of major cloud infrastructure, workflow platform, and data platform initiatives through production release.
  • Lead architecture and design reviews and influence technical decisions across the engineering team.
  • Mentor mid-level and junior engineers through code reviews, design documents, pairing, and example.
  • Build and improve AI-coding tools, including custom plugins, MCP servers, and agents.
  • Partner with scientists, bioinformaticians, R&D engineers, and the team lead on platform needs, roadmap, prioritization, and technical decisions.

Requirements

  • 10+ years of professional software engineering experience across varied systems and problem types.
  • Production experience designing for a major cloud platform, with AWS preferred and GCP or Azure accepted as equivalents.
  • Production experience with Kubernetes or an equivalent container-orchestration platform, including cluster design, scheduling, networking, and workload patterns.
  • Production experience with Terraform or an equivalent infrastructure-as-code tool, including shared modules and multi-environment deployments.
  • Strong proficiency in at least one general-purpose programming language such as Python, Go, or Java, with the ability to learn new languages and use AI tooling effectively.
  • Experience shipping software to internal or external end users and understanding product delivery realities.
  • Previous engineering team leadership, mentorship of junior engineers, and ownership of multi-quarter technical initiatives.
  • Experience working in fast-moving, startup-like environments with rapid, MVP-first delivery.
  • Familiarity with AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, and React.
  • Preferred experience in scientific or bioinformatics computing, LIMS or laboratory data systems, workflow orchestration, ETL or data pipelines, or HPC and batch-compute platforms; relevant examples include Airflow, Argo, Temporal, and Dagster.

Benefits

  • Competitive base salary plus an annual performance incentive bonus and long-term equity awards.
  • Comprehensive medical, dental, vision, life, disability, fertility-care, and related health benefits.
  • 401(k) benefits with company match, generous paid time off, company holidays, commuter benefits, wellness and work-life benefits, pregnancy and baby-bonding leave, and an employee referral program.
  • South San Francisco, California is preferred, with remote work optional; the position is full-time.

Tech Stack

Categories

Natera

About Natera

5,001-10,000 employees

Natera develops and sells cell-free DNA-based diagnostic tests for oncology, women’s health, and organ transplant care, used by hospitals and clinicians. Its portfolio includes non-invasive prenatal testing and carrier screening, minimal residual disease monitoring for cancer, and transplant rejection assessment, delivered as CLIA/CAP-accredited lab services. Founded in 2004 and headquartered in Austin, Texas, Natera is a public company listed on NASDAQ.

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