Sequencing

Senior Backend Engineer (Agentic Data Platform)

Sequencing
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2 months ago
Remote, United StatesSenior

Responsibilities

  • Develop and maintain high-performance, fault-tolerant distributed backend services.
  • Build and optimize large-scale genomic and health data processing pipelines using Apache Spark and DuckDB.
  • Design data structures, storage, and indexing strategies across PostgreSQL, Qdrant, and Redis.
  • Own asynchronous event processing and workflow orchestration using AWS SQS, RabbitMQ, and BullMQ.
  • Improve latency, throughput, and reliability through parallel execution, caching, and efficient data access.
  • Build guardrail and quality-assurance layers that ground AI responses in genomic and scientific evidence.
  • Partner with bioinformatics experts and product/design specialists on scientifically accurate and user-facing behavior.

Requirements

  • 5+ years of experience building and operating production backend systems at scale.
  • Expert-level TypeScript experience and the ability to own production services end to end.
  • Strong distributed-systems fundamentals and practical experience with systems that operate at scale.
  • Hands-on experience with large-scale data processing frameworks such as Apache Spark and very large datasets.
  • Deep familiarity with OLTP and OLAP data systems, including PostgreSQL and DuckDB.
  • Experience with distributed event-driven systems.
  • Ability to learn and work deeply in unfamiliar domains such as genomics.
  • Preferred qualifications include Rust, functional programming with Scala or similar, Python for data processing, AI model training or fine-tuning, multi-agent AI orchestration, LLM APIs, vector databases, RAG pipelines, LLM observability tools, Temporal, genomics or bioinformatics, health data systems, and high-growth startup experience.

Benefits

  • Fully remote role open to candidates in time zones from UTC−5 to UTC+3.
  • Opportunity to work on a category-defining product at the intersection of genomics, health data, and AI.

Tech Stack

Categories

BackendData Engineering
Sequencing

About Sequencing

11-50 employees
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